Jan 27, · The potent vasoconstrictor peptide endothelin-1 (ET-1) was first isolated from the culture media of porcine endothelial cells in (Yanagisawa et al, ).It is one of a family of multifunctional peptides (ET-1, 2 and 3) that are closely related to the sarafotoxins derived from the venom of Cited by: Jul 25, · Fischgräbe, J. et al. Targeting endothelin A receptor enhances anti-proliferative and anti-invasive effects of the HER2 antibody trastuzumab in HER2-overexpressing breast cancer cells. Int. J.
Sep 15, · Schrey M. P., Patel K. V., Tezapsidis N. Bombesin and glucocorticoids stimulate human breast cancer cells to produce endothelin, a paracrine mitogen for breast stromal cells. Cancer Res., , Cited by: Endothelin in Breast Cancer Breast epithelial cells regularly produce and secrete ET-1 in small quantities. Similar to the excessively high concentrations of endothelin in prostate cancer cells, endothelin and its receptors are overly expressed in breast cancer.
Jan 23, · The endothelin axis is also active in cancer, but its role is unclear. The cancers that commonly cause osteoblastic metastases, breast and prostate, express ET‐1 and receptors, suggesting that tumor‐produced ET‐1 may have paracrine (on bone cells) and/or autocrine (on tumor growth and apoptosis) bihada-josei.info by: Mar 22, · Endothelin receptor B (EDNRB) is one of the receptors in the endothelin axis and its upregulated expression is associated with tumorigenesis and metastasis of several types of solid tumors. However, the expression profile of EDNRB in breast cancer and its role in the progression of breast cancer are bihada-josei.info: Xi Gu, Shuai Han, Meizi Cui, Jinqi Xue, Liping Ai, Lisha Sun, Xudong Zhu, Yulun Wang, Caigang Liu.